As of my last knowledge update in September 2021, I can provide you with a list of some highly-rated and popular Melbourne Hotel. Please keep in mind that the hotel industry is dynamic, and rankings can change over time. To ensure the most up-to-date information and to make reservations, I recommend checking recent reviews and booking platforms. Here are 16 well-regarded hotels in Melbourne:

1. The Langham, Melbourne: A luxurious hotel located on the Southbank Promenade, offering beautiful views and excellent amenities.
2. Crown Towers Melbourne: Part of the Crown Melbourne complex, this upscale hotel offers luxury accommodations, dining, and entertainment options.
3. QT Melbourne: A stylish boutique hotel with unique design elements, located in the heart of the city.
4. The Ritz-Carlton, Melbourne: A high-end hotel offering elegance and luxury, situated in a prime location in the CBD.
5. Sofitel Melbourne on Collins: A luxury hotel with elegant rooms and dining options, offering views of Melbourne’s skyline.
6. The Westin Melbourne: A well-regarded hotel known for its comfortable rooms and central location near landmarks like Federation Square.
7. Park Hyatt Melbourne: A luxury hotel set in a historic building, offering a tranquil atmosphere in the heart of the city.
8. InterContinental Melbourne The Rialto: Located in a beautifully restored historic building, this hotel offers a blend of classic and modern luxury.
9. Adelphi Hotel Melbourne: A boutique hotel known for its contemporary design and rooftop pool.
10. Ovolo Laneways: A stylish boutique hotel located in Melbourne’s laneways, offering modern accommodations with a creative flair.
11. The Windsor: A historic and iconic hotel in Melbourne, known for its classic elegance and timeless charm.
12. The Blackman Hotel: Part of the Art Series Hotels, this unique hotel showcases contemporary art in a boutique setting.
13. The Larwill Studio: Another Art Series Hotel, known for its artistic and colorful design, located near the Royal Children’s Hospital.
14. Hotel Lindrum Melbourne: A boutique hotel offering a blend of classic and contemporary design, located near Flinders Street Station.
15. Coppersmith Hotel: A boutique hotel with a modern Australian pub, offering a unique and charming experience in South Melbourne.
16. Melbourne Marriott Hotel: Located in the CBD, this upscale hotel offers comfortable accommodations and is within walking distance of many attractions.

Please note that the availability and quality of these hotels can vary, and it’s advisable to check recent reviews, ratings, and current pricing when making reservations. Melbourne has a diverse range of hotels to suit various budgets and preferences, so you’re likely to find accommodation that meets your specific needs.